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Strain-Promoted Crosslinking of PEG-based Hydrogels via Copper-Free Cycloaddition.

ABSTRACT: The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized polyethylene glycol (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative in which to encapsulate cells that are sensitive to photochemical or chemical crosslinking mechanisms.

SUBMITTER: Zheng J

PROVIDER: S-EPMC3507357 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Strain-Promoted Crosslinking of PEG-based Hydrogels via Copper-Free Cycloaddition.

Zheng Jukuan J Smith Callahan Laura A LA Hao Jinkun J Guo Kai K Wesdemiotis Chrys C Weiss R A RA Becker Matthew L ML

ACS macro letters 20120801 8

The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized polyethylene glycol (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative in which to encapsulate cells that are sensitive to photochemical or chemical crosslinking mechanisms. ...[more]

PMID: 23205321

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