DNA-based delivery vehicles: pH-controlled disassembly and cargo release.
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ABSTRACT:
SUBMITTER: Keum JW
PROVIDER: S-EPMC3508031 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
DNA-based delivery vehicles: pH-controlled disassembly and cargo release.
Keum Jung-Won JW Bermudez Harry H
Chemical communications (Cambridge, England) 20121112 99
Non-Watson-Crick base pairing provides an in situ approach for actuation of DNA nanostructures through responses to solution conditions. Here we demonstrate this concept by using physiologically-relevant changes in pH to regulate DNA pyramid assembly/disassembly and to control the release of protein cargo. ...[more]
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