Ontology highlight
ABSTRACT:
SUBMITTER: Rossetti M
PROVIDER: S-EPMC5452262 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chemical science 20161103 2
Here we demonstrate the rational design of a new class of DNA-based nanoswitches which are allosterically regulated by specific biological targets, antibodies and transcription factors, and are able to load and release a molecular cargo (<i>i.e.</i> doxorubicin) in a controlled fashion. In our first model system we rationally designed a stem-loop DNA-nanoswitch that adopts two mutually exclusive conformations: a "Load" conformation containing a doxorubicin-intercalating domain and a "Release" co ...[more]