Monoclonal antibodies: versatile platforms for cancer immunotherapy.
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ABSTRACT:
SUBMITTER: Weiner LM
PROVIDER: S-EPMC3508064 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Monoclonal antibodies: versatile platforms for cancer immunotherapy.
Weiner Louis M LM Surana Rishi R Wang Shangzi S
Nature reviews. Immunology 20100501 5
Antibodies are important therapeutic agents for cancer. Recently, it has become clear that antibodies possess several clinically relevant mechanisms of action. Many clinically useful antibodies can manipulate tumour-related signalling. In addition, antibodies exhibit various immunomodulatory properties and, by directly activating or inhibiting molecules of the immune system, antibodies can promote the induction of antitumour immune responses. These immunomodulatory properties can form the basis ...[more]
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