Ontology highlight
ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC5095608 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Lee Ju Yeon JY Lee Hyun Tae HT Shin Woori W Chae Jongseok J Choi Jaemo J Kim Sung Hyun SH Lim Heejin H Won Heo Tae T Park Kyeong Young KY Lee Yeon Ji YJ Ryu Seong Eon SE Son Ji Young JY Lee Jee Un JU Heo Yong-Seok YS
Nature communications 20161031
Cancer cells express tumour-specific antigens derived via genetic and epigenetic alterations, which may be targeted by T-cell-mediated immune responses. However, cancer cells can avoid immune surveillance by suppressing immunity through activation of specific inhibitory signalling pathways, referred to as immune checkpoints. In recent years, the blockade of checkpoint molecules such as PD-1, PD-L1 and CTLA-4, with monoclonal antibodies has enabled the development of breakthrough therapies in onc ...[more]