Ontology highlight
ABSTRACT:
SUBMITTER: Zielinska AK
PROVIDER: S-EPMC3508076 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Zielinska Agnieszka K AK Beenken Karen E KE Mrak Lara N LN Spencer Horace J HJ Post Ginell R GR Skinner Robert A RA Tackett Alan J AJ Horswill Alexander R AR Smeltzer Mark S MS
Molecular microbiology 20121017 5
Mutation of staphylococcal accessory regulator (sarA) results in increased production of extracellular proteases in Staphylococcus aureus, which has been correlated with decreased biofilm formation and decreased accumulation of extracellular toxins. We used murine models of implant-associated biofilm infection and S. aureus bacteraemia (SAB) to compare virulence of USA300 strain LAC, its isogenic sarA mutant, and derivatives of each of these strains with mutations in all 10 of the genes encoding ...[more]