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Harnessing plasticity to understand learning and treat disease.

ABSTRACT: A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest how plasticity might be targeted to reset dysfunctional circuits. Specifically, a new model is proposed in which map expansion provides a form of replication with variation that supports a Darwinian mechanism to select the most behaviorally useful circuits. Precisely targeted neural plasticity provides a new avenue for the treatment of neurological and psychiatric disorders and is a powerful tool to test the neural mechanisms of learning and memory.

SUBMITTER: Kilgard MP

PROVIDER: S-EPMC3508154 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Harnessing plasticity to understand learning and treat disease.

Kilgard Michael P MP

Trends in neurosciences 20120927 12

A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest how plasticity might be targeted to reset dysfunctional circuits. Specifically, a new model is proposed in which map expansion provides a form of replication with variation that supp ...[more]

PMID: 23021980

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