Ontology highlight
ABSTRACT:
SUBMITTER: Huang CH
PROVIDER: S-EPMC3508381 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Huang Ching-Hui CH Nwe Kido K Al Zaki Ajlan A Brechbiel Martin W MW Tsourkas Andrew A
ACS nano 20121029 11
Gadolinium-conjugated dendrimer nanoclusters (DNCs) are a promising platform for the early detection of disease; however, their clinical utility is potentially limited due to safety concerns related to nephrogenic systemic fibrosis (NSF). In this paper, biodegradable DNCs were prepared with polydisulfide linkages between the individual dendrimers to facilitate excretion. Further, DNCs were labeled with premetalated Gd chelates to eliminate the risk of free Gd becoming entrapped in dendrimer cavi ...[more]