Ontology highlight
ABSTRACT:
SUBMITTER: Tharin S
PROVIDER: S-EPMC3508722 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Tharin Suzanne S Kothapalli Chandrasekhar R CR Ozdinler Pembe Hande PH Pasquina Lincoln L Chung Seok S Varner Johanna J DeValence Sarra S Kamm Roger R Macklis Jeffrey D JD
Integrative biology : quantitative biosciences from nano to macro 20121101 11
While much is known about general controls over axon guidance of broad classes of projection neurons (those with long-distance axonal connections), molecular controls over specific axon targeting by distinct neuron subtypes are poorly understood. Corticospinal motor neurons (CSMN) are prototypical and clinically important cerebral cortex projection neurons; they are the brain neurons that degenerate in amyotrophic lateral sclerosis (ALS) and related motor neuron diseases, and their injury is cen ...[more]