Ontology highlight
ABSTRACT:
SUBMITTER: Serrano A
PROVIDER: S-EPMC3509593 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Serrano Ana A Frago Susana S Velázquez-Campoy Adrián A Medina Milagros M
International journal of molecular sciences 20121108 11
In mammals and in yeast the conversion of Riboflavin (RF) into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) is catalysed by the sequential action of two enzymes: an ATP:riboflavin kinase (RFK) and an ATP:FMN adenylyltransferase (FMNAT). However, most prokaryotes depend on a single bifunctional enzyme, FAD synthetase (FADS), which folds into two modules: the C-terminal associated with RFK activity and the N-terminal associated with FMNAT activity. Sequence and structural ana ...[more]