Ontology highlight
ABSTRACT:
SUBMITTER: Goodnough LH
PROVIDER: S-EPMC3509735 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Goodnough L Henry LH Chang Andrew T AT Treloar Charles C Yang Jing J Scacheri Peter C PC Atit Radhika P RP
Development (Cambridge, England) 20121024 23
The bones of the mammalian skull vault form through intramembranous ossification. Skull bones ossify directly, in a process regulated by β-catenin, instead of passing through a cartilage intermediate. We tested whether β-catenin is necessary for fate selection of intramembranous bone progenitors in the skull. Here, we show in mice that removal of β-catenin from skull bone progenitors results in the near complete transformation of the skull bones to cartilage, whereas constitutive β-catenin activ ...[more]