Dataset Information

Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

ABSTRACT:

Purpose

This study investigated the anti-tumour effects of the novel vascular disrupting agent plinabulin (NPI-2358) when given alone or combined with radiation.

Materials and methods

Foot implanted C3H mammary carcinomas or leg implanted KHT sarcomas were used, with plinabulin injected intraperitoneally. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measurements were made with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) on a 7-tesla magnet. Treatment response was assessed using regrowth delay (C3H tumours), clonogenic survival (KHT sarcomas) or histological estimates of necrosis for both models.

Results

Plinabulin (7.5 mg/kg) significantly reduced the initial area under curve (IAUC) and the transfer constant (K(trans)) within 1 hour after injection, reaching a nadir at 3 h, but returning to normal within 24 h. A dose-dependent decrease in IAUC and K(trans), was seen at 3 h. No significant anti-tumour effects were observed in the C3H tumours until doses of 12.5 mg/kg were achieved, but started at 1.5 mg/kg in the KHT sarcoma. Irradiating tumours 1 h after injecting plinabulin enhanced response in both models.

Conclusions

Plinabulin induced a time- and dose-dependent decrease in tumour perfusion. The KHT sarcoma was more sensitive than the C3H tumour to the anti-tumour effects of plinabulin, while radiation response was enhanced in both models.

SUBMITTER: Bertelsen LB

PROVIDER: S-EPMC3509771 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Publications

Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

Bertelsen Lotte B LB Shen Yuan Yuan YY Nielsen Thomas T Stødkilde-Jørgensen Hans H Lloyd G Kenneth GK Siemann Dietmar W DW Horsman Michael R MR

International journal of radiation biology 20111101 11

<h4>Purpose</h4>This study investigated the anti-tumour effects of the novel vascular disrupting agent plinabulin (NPI-2358) when given alone or combined with radiation.<h4>Materials and methods</h4>Foot implanted C3H mammary carcinomas or leg implanted KHT sarcomas were used, with plinabulin injected intraperitoneally. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measurements were made with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) on a 7-tesla magnet. Treatment ...[more]

PMID: 21815749

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Dataset Information

Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

Purpose

Materials and methods

Results

Conclusions

Publications

Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.

Similar Datasets

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