Ontology highlight
ABSTRACT:
SUBMITTER: Whitcomb DC
PROVIDER: S-EPMC3510344 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20121111 12
Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 (P < 1 × 10(-12)) and X-linked CLDN2 (P < 1 × 10(-21)) through a two-stage genome-wide study (stage 1: 676 cases a ...[more]