Ontology highlight
ABSTRACT:
SUBMITTER: Ragunathan K
PROVIDER: S-EPMC3510455 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ragunathan Kaushik K Liu Cheng C Ha Taekjip T
eLife 20121213
During homologous recombination, RecA forms a helical filament on a single stranded (ss) DNA that searches for a homologous double stranded (ds) DNA and catalyzes the exchange of complementary base pairs to form a new heteroduplex. Using single molecule fluorescence imaging tools with high spatiotemporal resolution we characterized the encounter complex between the RecA filament and dsDNA. We present evidence in support of the 'sliding model' wherein a RecA filament diffuses along a dsDNA track. ...[more]