Ontology highlight
ABSTRACT:
SUBMITTER: Lucarelli D
PROVIDER: S-EPMC2749006 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Lucarelli Debora D Wang Ying A YA Galkin Vitold E VE Yu Xiong X Wigley Dale B DB Egelman Edward H EH
Journal of molecular biology 20090621 2
The E. coli RecBCD enzyme facilitates the loading of RecA onto single-stranded DNA produced by the combined helicase/nuclease activity of RecBCD. The nuclease domain of RecB protein, RecB(nuc), has been previously shown to bind RecA. Surprisingly, RecB(nuc) also binds to phage and eukaryotic homologs of RecA, leading to the suggestion that RecB(nuc) interacts with the polymerization motif that is present in all three proteins. This mode of interaction could only be with monomeric RecA, as this m ...[more]