Ontology highlight
ABSTRACT:
SUBMITTER: Morgan DJ
PROVIDER: S-EPMC3510705 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Morgan Daniel J DJ Wei Suwen S Gomes Ivone I Czyzyk Traci T Mzhavia Nino N Pan Hui H Devi Lakshmi A LA Fricker Lloyd D LD Pintar John E JE
Journal of neurochemistry 20100326 5
Mice with a targeted mutation in proSAAS have been generated to investigate whether peptides derived from this precursor could function as an inhibitor of prohormone convertase 1/3 (PC1/3) in vivo as well as to determine any alternate roles for proSAAS in nervous and endocrine tissues. Fetal mice lacking proSAAS exhibit complete, adult-like processing of prodynorphin in the prenatal brain instead of the incomplete processing seen in the brains of wild-type fetal mice where inhibitory proSAAS int ...[more]