Ontology highlight
ABSTRACT:
SUBMITTER: Inoue F
PROVIDER: S-EPMC6750255 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Inoue Fumitaka F Eckalbar Walter L WL Wang Yi Y Murphy Karl K KK Matharu Navneet N Vaisse Christian C Ahituv Nadav N
Nature metabolism 20190408 4
Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system. However, due to the difficulties in isolating and characterizing specific neuronal subpopulations, few obesity-associated SNPs have been functionally characterized. Leptin responsive neurons in the hypothalamus are essential in controlling energy homeostasis and body weight. Here, we combine FACS-sorting of leptin-responsive hypothalamic n ...[more]