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Acylsulfonamide safety-catch linker: promise and limitations for solid-phase oligosaccharide synthesis.

ABSTRACT: Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis.

SUBMITTER: Yin J 

PROVIDER: S-EPMC3511041 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Acylsulfonamide safety-catch linker: promise and limitations for solid-phase oligosaccharide synthesis.

Yin Jian J   Eller Steffen S   Collot Mayeul M   Seeberger Peter H PH  

Beilstein journal of organic chemistry 20121126

Safety-catch linkers are useful for solid-phase oligosaccharide synthesis as they are orthogonal to many common protective groups. A new acylsulfonamide safety-catch linker was designed, synthesized and employed during glycosylations using an automated carbohydrate synthesizer. The analysis of the cleavage products revealed shortcomings for oligosaccharide synthesis. ...[more]

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