Dataset Information

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

ABSTRACT: Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and contributes to the control of secondary infections. However, little is known about how tissue-resident memory T cells behave in situ and how they encounter newly infected target cells. Here we demonstrate that antigen-specific CD8(+) T cells that remain in skin following herpes simplex virus infection show a steady-state crawling behavior in between keratinocytes. Spatially explicit simulations of the migration of these tissue-resident memory T cells indicate that the migratory dendritic behavior of these cells allows the detection of antigen-expressing target cells in physiologically relevant time frames of minutes to hours. Furthermore, we provide direct evidence for the identification of rare antigen-expressing epithelial cells by skin-patrolling memory T cells in vivo. These data demonstrate the existence of skin patrol by memory T cells and reveal the value of this patrol in the rapid detection of renewed infections at a previously infected site.

SUBMITTER: Ariotti S

PROVIDER: S-EPMC3511734 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

Ariotti Silvia S Beltman Joost B JB Chodaczek Grzegorz G Hoekstra Mirjam E ME van Beek Anna E AE Gomez-Eerland Raquel R Ritsma Laila L van Rheenen Jacco J Marée Athanasius F M AF Zal Tomasz T de Boer Rob J RJ Haanen John B A G JB Schumacher Ton N TN

Proceedings of the National Academy of Sciences of the United States of America 20121112 48

Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and contributes to the control of secondary infections. However, little is known about how tissue-resident memory T cells behave in situ and how they encounter newly infected target cells. Here we demonstrate that antigen-specific CD8(+) T cells that remain in skin following herpes simplex virus infection show a steady-state crawling behavior in betwee ...[more]

PMID: 23150545

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Dataset Information

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

Publications

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

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