Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC3513937 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Chemical science 20120101 12
Fusarisetin A (1) is a recently isolated natural product that displays an unprecedented chemical motif and remarkable bioactivities as a potent cancer migration inhibitor. We describe here our studies leading to an efficient and scalable total synthesis of 1. Essential to the strategy was the development of a new route for the formation of a trans-decalin moiety of this compound and the application of an oxidative radical cyclization (ORC) reaction that produces fusarisetin A (1) from equisetin ...[more]