Ontology highlight
ABSTRACT:
SUBMITTER: Burns NZ
PROVIDER: S-EPMC2740483 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20090701 26
A total synthesis of the complex, bent aromatic ring-containing marine alkaloid haouamine A is achieved through a route in which every step (with the exception of the final deprotection) is performed on a gram-scale. This is accomplished through the development of a method for the dehydrogenation of cyclohexenones that allows for point-to-planar chirality transfer. This strategy makes it possible to program the desired atropisomeric outcome from a simple chiral cyclohexenone. By synthesizing atr ...[more]