Ontology highlight
ABSTRACT:
SUBMITTER: Durie D
PROVIDER: S-EPMC3514411 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Durie D D Lewis S M SM Liwak U U Kisilewicz M M Gorospe M M Holcik M M
Oncogene 20101122 12
Expression of the intrinsic cellular caspase inhibitor XIAP is regulated primarily at the level of protein synthesis. The 5' untranslated region harbours an Internal Ribosome Entry Site (IRES) motif that supports cap-independent translation of XIAP mRNA during conditions of cellular stress. In this study, we show that the RNA-binding protein HuR, which is known to orchestrate an antiapoptotic cellular program, stimulates translation of XIAP mRNA through XIAP IRES. We further show that HuR binds ...[more]