Ontology highlight
ABSTRACT:
SUBMITTER: Borgia A
PROVIDER: S-EPMC3514500 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Borgia Alessandro A Wensley Beth G BG Soranno Andrea A Nettels Daniel D Borgia Madeleine B MB Hoffmann Armin A Pfeil Shawn H SH Lipman Everett A EA Clarke Jane J Schuler Benjamin B
Nature communications 20120101
Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it has remained unclear how this contribution is distributed along the reaction and what influence it has on the folding dynamics. Here we use a combination of single-molecule Förster re ...[more]