Ontology highlight
ABSTRACT:
SUBMITTER: Zheng W
PROVIDER: S-EPMC4379956 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Zheng Wenwei W De Sancho David D Hoppe Travis T Best Robert B RB
Journal of the American Chemical Society 20150227 9
An outstanding challenge in protein folding is understanding the origin of "internal friction" in folding dynamics, experimentally identified from the dependence of folding rates on solvent viscosity. A possible origin suggested by simulation is the crossing of local torsion barriers. However, it was unclear why internal friction varied from protein to protein or for different folding barriers of the same protein. Using all-atom simulations with variable solvent viscosity, in conjunction with tr ...[more]