Ontology highlight
ABSTRACT:
SUBMITTER: Weigandt KM
PROVIDER: S-EPMC3514520 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Weigandt Katie M KM White Nathan N Chung Dominic D Ellingson Erica E Wang Yi Y Fu Xiaoyun X Pozzo Danilo C DC
Biophysical journal 20121201 11
Using a combination of structural and mechanical characterization, we examine the effect of fibrinogen oxidation on the formation of fibrin clots. We find that treatment with hypochlorous acid preferentially oxidizes specific methionine residues on the α, β, and γ chains of fibrinogen. Oxidation is associated with the formation of a dense network of thin fibers after activation by thrombin. Additionally, both the linear and nonlinear mechanical properties of oxidized fibrin gels are found to be ...[more]