The prenyl-binding protein PrBP/?: a chaperone participating in intracellular trafficking.
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ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC3514561 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
The prenyl-binding protein PrBP/δ: a chaperone participating in intracellular trafficking.
Zhang Houbin H Constantine Ryan R Frederick Jeanne M JM Baehr Wolfgang W
Vision research 20120829
Expressed ubiquitously, PrBP/δ functions as chaperone/co-factor in the transport of a subset of prenylated proteins. PrBP/δ features an immunoglobulin-like β-sandwich fold for lipid binding, and interacts with diverse partners. PrBP/δ binds both C-terminal C15 and C20 prenyl side chains of phototransduction polypeptides and small GTP-binding (G) proteins of the Ras superfamily. PrBP/δ also interacts with the small GTPases, ARL2 and ARL3, which act as release factors (GDFs) for prenylated cargo. ...[more]
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