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Colorimetric protein sensing using catalytically amplified sensor arrays.

ABSTRACT: Catalytically active iron oxide nanoparticles are used as recognition elements and signal amplifiers for the array-based colorimetric sensing of proteins. Interactions between cationic monolayers on the Fe(3) O(4) NPs and analyte proteins differentially modulates the peroxidase-like activity of Fe(3) O(4) NPs, affording catalytically amplified colorimetric signal patterns that enable the detection and identification of proteins at 50 nM.

SUBMITTER: Li X 

PROVIDER: S-EPMC3514658 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Colorimetric protein sensing using catalytically amplified sensor arrays.

Li Xiaoning X   Wen Fang F   Creran Brian B   Jeong Youngdo Y   Zhang Xinrong X   Rotello Vincent M VM  

Small (Weinheim an der Bergstrasse, Germany) 20120907 23

Catalytically active iron oxide nanoparticles are used as recognition elements and signal amplifiers for the array-based colorimetric sensing of proteins. Interactions between cationic monolayers on the Fe(3) O(4) NPs and analyte proteins differentially modulates the peroxidase-like activity of Fe(3) O(4) NPs, affording catalytically amplified colorimetric signal patterns that enable the detection and identification of proteins at 50 nM. ...[more]

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