Ontology highlight
ABSTRACT:
SUBMITTER: Faucher F
PROVIDER: S-EPMC3515362 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Faucher Frédérick F Jia Zongchao Z
Acta crystallographica. Section F, Structural biology and crystallization communications 20121026 Pt 11
Aldo-keto reductase 1a4 (AKR1a4; EC 1.1.1.2) is the mouse orthologue of human aldehyde reductase (AKR1a1), the founding member of the AKR family. As an NADPH-dependent enzyme, AKR1a4 catalyses the conversion of D-glucuronate to L-gulonate. AKR1a4 is involved in ascorbate biosynthesis in mice, but has also recently been found to interact with SMAR1, providing a novel mechanism of ROS regulation by ATM. Here, the crystal structure of AKR1a4 in its apo form at 1.64 Å resolution as well as the chara ...[more]