Ontology highlight
ABSTRACT:
SUBMITTER: Heise CE
PROVIDER: S-EPMC3515450 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20121205 12
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase-6 that acts by an uncompetitive binding mode that is an unprecedented mechanism of inhibition against this target class. Biochemical assays demonstrate that, while exquisitely selective for caspase-6 over caspase-3 and -7, the compound's inhibitory ...[more]