Ontology highlight
ABSTRACT:
SUBMITTER: Rai G
PROVIDER: S-EPMC3515842 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Rai Ganesha G Vyjayanti Vaddadi N VN Dorjsuren Dorjbal D Simeonov Anton A Jadhav Ajit A Wilson David M DM Maloney David J DJ
Journal of medicinal chemistry 20120328 7
APE1 is an essential protein that operates in the base excision repair (BER) pathway and is responsible for ≥95% of the total apurinic/apyrimidinic (AP) endonuclease activity in human cells. BER is a major pathway that copes with DNA damage induced by several anticancer agents, including ionizing radiation and temozolomide. Overexpression of APE1 and enhanced AP endonuclease activity have been linked to increased resistance of tumor cells to treatment with monofunctional alkylators, implicating ...[more]