Ontology highlight
ABSTRACT:
SUBMITTER: Fedoriw AM
PROVIDER: S-EPMC3516474 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Fedoriw Andrew M AM Calabrese J Mauro JM Mu Weipeng W Yee Della D Magnuson Terry T
G3 (Bethesda, Md.) 20121201 12
The organization of the genome within the mammalian nucleus is nonrandom, with physiologic processes often concentrated in specific three-dimensional domains. This organization may be functionally related to gene regulation and, as such, may play a role in normal development and human disease processes. However, the mechanisms that participate in nuclear organization are poorly understood. Here, we present data characterizing localization of the imprinted Kcnq1 alleles. We show that nucleolar as ...[more]