Ontology highlight
ABSTRACT:
SUBMITTER: Ochiana SO
PROVIDER: S-EPMC3516633 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20120731
New drugs for neglected tropical diseases such as human African trypanosomiasis (HAT) are needed, yet drug discovery efforts are not often focused on this area due to cost. Target repurposing, achieved by the matching of essential parasite enzymes to those human enzymes that have been successfully inhibited by small molecule drugs, provides an attractive means by which new drug optimization programs can be pragmatically initiated. In this report we describe our results in repurposing an establis ...[more]