Ontology highlight
ABSTRACT:
SUBMITTER: Almabruk KH
PROVIDER: S-EPMC3517013 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Almabruk Khaled H KH Asamizu Shumpei S Chang Ada A Varghese Sheril G SG Mahmud Taifo T
Chembiochem : a European journal of chemical biology 20120907 15
From A to B: Through detailed biochemical investigations, we discovered that VldW, an α-ketoglutarate/Fe(II)-dependent dioxygenase, regioselectively hydroxylates validamycin A to validamycin B. The results provide insights into the biosynthesis of hydroxylated validamycins and could be used to control the metabolic outcomes of the validamycin pathway. ...[more]