Ontology highlight
ABSTRACT:
SUBMITTER: Lambe T
PROVIDER: S-EPMC3517112 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Lambe Teresa T Crawford Greg G Johnson Andy L AL Crockford Tanya L TL Bouriez-Jones Tiphaine T Smyth Aisling M AM Pham Trung H M TH Zhang Qian Q Freeman Alexandra F AF Cyster Jason G JG Su Helen C HC Cornall Richard J RJ
European journal of immunology 20111110 12
Deficiency in the guanine nucleotide exchange factor dedicator of cytokinesis 8 (DOCK8) causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and viral infections. We have recently identified a DOCK8-deficient mouse strain, carrying an ethylnitrosourea-induced splice-site mutation that shows a failure to mature a humoral immune response due to the loss of germinal centre B cells. In this study, we turned to T-cell immunity to investigate further the human immunodeficie ...[more]