Ontology highlight
ABSTRACT:
SUBMITTER: Kim IH
PROVIDER: S-EPMC3517215 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110221 6
Structure-activity relationships of cycloalkylamide compounds as inhibitors of human sEH were investigated. When the left side of amide function was modified by a variety of cycloalkanes, at least a C6 like cyclohexane was necessary to yield reasonable inhibition potency on the target enzyme. In compounds with a smaller cycloalkane or with a polar group on the left side of amide function, no inhibition was observed. On the other hand, increased hydrophobicity dramatically improved inhibition pot ...[more]