Ontology highlight
ABSTRACT:
SUBMITTER: Bar-Peled L
PROVIDER: S-EPMC3517996 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Bar-Peled Liron L Schweitzer Lawrence D LD Zoncu Roberto R Sabatini David M DM
Cell 20120901 6
The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues, including amino acids, which promote mTORC1 translocation to the lysosomal surface, its site of activation. The heterodimeric RagA/B-RagC/D GTPases, the Ragulator complex that tethers the Rags to the lysosome, and the v-ATPase form a signaling system that is necessary for amino acid sensing by mTORC1. Amino acids stimulate the binding of guanosine triphosphate to RagA and RagB but the factors that regulate Ra ...[more]