Ontology highlight
ABSTRACT:
SUBMITTER: Schweitzer LD
PROVIDER: S-EPMC4570232 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Schweitzer Lawrence D LD Comb William C WC Bar-Peled Liron L Sabatini David M DM
Cell reports 20150820 9
mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase is activated downstream of growth factor signaling. mTORC1 is brought to the lysosome by the Rag GTPases, which are tethered to the lysosomal membrane by Ragulator, a lysosome-bound scaffold. Here, we identify c17orf59 as a Ragulator-interacting pro ...[more]