Ontology highlight
ABSTRACT:
SUBMITTER: Gurram V
PROVIDER: S-EPMC3518038 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Chemistry, an Asian journal 20120508 8
Reaction conditions for the CC cross-coupling of O(6)-alkyl-2-bromo- and 2-chloroinosine derivatives with aryl-, hetaryl-, and alkylboronic acids were studied. Optimization experiments with silyl-protected 2-bromo-O(6)-methylinosine led to the identification of [PdCl(2)(dcpf)]/K(3)PO(4) in 1,4-dioxane as the best conditions for these reactions (dcpf=1,1'-bis(dicyclohexylphosphino)ferrocene). Attempted O(6)-demethylation, as well as the replacement of the C-6 methoxy group by amines, was unsucce ...[more]