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One-Pot Synthesis of α-Alkyl Styrene Derivatives.

ABSTRACT: There is a significant need to develop more rapid and efficient routes to styrene derivatives, since they are extensively used in polymer sciences. This manuscript reports a one-pot synthesis of an array of α-alkyl styrene derivatives from readily available natural products (i.e., estragole and safrole). This method is regioselective, producing a rearranged adduct, under transition metal-free conditions. This methodology has broad nucleophile scope, even tolerating sterically hindered nucleophiles; it is general for carbon, nitrogen, oxygen, and sulfur nucleophiles.

SUBMITTER: Ojo OS

PROVIDER: S-EPMC8359136 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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One-Pot Synthesis of α-Alkyl Styrene Derivatives.

Ojo Olatunji S OS Bugarin Alejandro A

ACS omega 20210728 31

There is a significant need to develop more rapid and efficient routes to styrene derivatives, since they are extensively used in polymer sciences. This manuscript reports a one-pot synthesis of an array of α-alkyl styrene derivatives from readily available natural products (i.e., estragole and safrole). This method is regioselective, producing a rearranged adduct, under transition metal-free conditions. This methodology has broad nucleophile scope, even tolerating sterically hindered nucleophil ...[more]

PMID: 34396007

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