Ontology highlight
ABSTRACT:
SUBMITTER: Tormo-Mas MA
PROVIDER: S-EPMC3518041 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Tormo-Más María Angeles MA Mir Ignacio I Shrestha Archana A Tallent Sandra M SM Campoy Susana S Lasa Iñigo I Barbé Jordi J Novick Richard P RP Christie Gail E GE Penadés José R JR
Nature 20100516 7299
Staphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of approximately 15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently encapsidated in phage-like infectious particles, leading to extremely high frequencies of intra- as well as intergeneric transfer. In the absence of helper phage lytic growth, the island is maintained in a quiescent prophage-like state by a global repressor, Stl, which ...[more]