Ontology highlight
ABSTRACT:
SUBMITTER: Smith KT
PROVIDER: S-EPMC3518139 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Smith Karen T KT Sardiu Mihaela E ME Martin-Brown Skylar A SA Seidel Chris C Mushegian Arcady A Egidy Rhonda R Florens Laurence L Washburn Michael P MP Workman Jerry L JL
Molecular & cellular proteomics : MCP 20120914 12
Here we describe the function of a previously uncharacterized protein, named family with sequence similarity 60 member A (FAM60A) that maps to chromosome 12p11 in humans. We use quantitative proteomics to determine that the main biochemical partners of FAM60A are subunits of the Sin3 deacetylase complex and show that FAM60A resides in active HDAC complexes. In addition, we conduct gene expression pathway analysis and find that FAM60A regulates expression of genes that encode components of the TG ...[more]