Ontology highlight
ABSTRACT:
SUBMITTER: Clark MD
PROVIDER: S-EPMC5084087 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Clark Michael David MD Zhang Yongbo Y Radhakrishnan Ishwar I
Journal of molecular biology 20151106 24
The Sds3 transcriptional corepressor facilitates the assembly of the 1- to 2-MDa histone deacetylase-associated Sin3L/Rpd3L complex by providing a crucial homodimerization activity. Sds3 engages the scaffolding protein Sin3A, via a bipartite motif within the Sin3 interaction domain (SID) comprising a helix and an extended segment. Here, we show that the SID samples two discrete, substantially populated conformations with lifetimes in the tens of milliseconds range. The two conformations differ v ...[more]