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Reversible switching between epigenetic states in honeybee behavioral subcastes.

ABSTRACT: In honeybee societies, distinct caste phenotypes are created from the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phenotypes. We found no differences in DNA methylation between irreversible worker and queen castes, but substantial differences between nurses and forager subcastes. Reverting foragers back to nurses reestablished methylation levels for a majority of genes and provides, to the best of our knowledge, the first evidence in any organism of reversible epigenetic changes associated with behavior.

SUBMITTER: Herb BR

PROVIDER: S-EPMC3518384 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Reversible switching between epigenetic states in honeybee behavioral subcastes.

Herb Brian R BR Wolschin Florian F Hansen Kasper D KD Aryee Martin J MJ Langmead Ben B Irizarry Rafael R Amdam Gro V GV Feinberg Andrew P AP

Nature neuroscience 20120916 10

In honeybee societies, distinct caste phenotypes are created from the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phenotypes. We found no differences in DNA methylation between irreversible worker and queen castes, but substantial differences between nurses and forager subcastes. Reverting foragers back to nurses reestablished methylation levels for a majority of genes and provides, to the best of our knowledge, the first evidence in any organism of ...[more]

PMID: 22983211

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