Ontology highlight
ABSTRACT:
SUBMITTER: Nagai S
PROVIDER: S-EPMC3518492 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20081001 5901
Recent findings suggest important roles for nuclear organization in gene expression. In contrast, little is known about how nuclear organization contributes to genome stability. Epistasis analysis (E-MAP) using DNA repair factors in yeast indicated a functional relationship between a nuclear pore subcomplex and Slx5/Slx8, a small ubiquitin-like modifier (SUMO)-dependent ubiquitin ligase, which we show physically interact. Real-time imaging and chromatin immunoprecipitation confirmed stable recru ...[more]