Ontology highlight
ABSTRACT:
SUBMITTER: Poulsen SL
PROVIDER: S-EPMC3678163 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Poulsen Sara L SL Hansen Rebecca K RK Wagner Sebastian A SA van Cuijk Loes L van Belle Gijsbert J GJ Streicher Werner W Wikström Mats M Choudhary Chunaram C Houtsmuller Adriaan B AB Marteijn Jurgen A JA Bekker-Jensen Simon S Mailand Niels N
The Journal of cell biology 20130601 6
Protein modifications by ubiquitin and small ubiquitin-like modifier (SUMO) play key roles in cellular signaling pathways. SUMO-targeted ubiquitin ligases (STUbLs) directly couple these modifications by selectively recognizing SUMOylated target proteins through SUMO-interacting motifs (SIMs), promoting their K48-linked ubiquitylation and degradation. Only a single mammalian STUbL, RNF4, has been identified. We show that human RNF111/Arkadia is a new STUbL, which used three adjacent SIMs for spec ...[more]