Ontology highlight
ABSTRACT:
SUBMITTER: Diao J
PROVIDER: S-EPMC3518844 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Nature communications 20100810
The in vitro studies of membrane fusion mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) have primarily been conducted by following the mixing of lipids. However, the formation of a fusion pore and its expansion has been difficult to detect directly because of the leakiness of proteoliposomes, vesicle aggregation and rupture that often complicate the interpretation of ensemble fusion experiments. Fusion pore expansion is an essential step for full-colla ...[more]