Ontology highlight
ABSTRACT:
SUBMITTER: Hede MS
PROVIDER: S-EPMC3519493 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hede Marianne Smedegaard MS Salimova Ekaterina E Piszczek Agnieszka A Perlas Emarald E Winn Nadine N Nastasi Tommaso T Rosenthal Nadia N
PloS one 20121210 12
Insulin-like growth factor 1 (IGF-1) is a potent cytoprotective growth factor that has attracted considerable attention as a promising therapeutic agent. Transgenic over-expression of IGF-1 propeptides facilitates protection and repair in a broad range of tissues, although transgenic mice over-expressing IGF-1 propeptides display little or no increase in IGF-1 serum levels, even with high levels of transgene expression. IGF-1 propeptides are encoded by multiple alternatively spliced transcripts ...[more]