Ontology highlight
ABSTRACT:
SUBMITTER: Rizzi C
PROVIDER: S-EPMC3519572 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Rizzi Caroline C Bianco María Verónica MV Blanco Federico Carlos FC Soria Marcelo M Gravisaco María José MJ Montenegro Valeria V Vagnoni Lucas L Buddle Bryce B Garbaccio Sergio S Delgado Fernando F Leal Karen Silva KS Cataldi Angel Adrián AA Dellagostin Odir Antônio OA Bigi Fabiana F
PloS one 20121210 12
Mycobacterium bovis is the causative agent of tuberculosis in cattle but also infects other animals, including humans. Previous studies in cattle have demonstrated that the protection induced by BCG is not complete. In order to improve the protection efficacy of BCG, in this study we overexpressed Ag85B in a BCG Pasteur strain, by using an expression system based on the use of an auxotrophic strain for the leucine amino acid, and complementation with leuD. We found that vaccination of cattle wit ...[more]