Ontology highlight
ABSTRACT:
SUBMITTER: Xu ZZ
PROVIDER: S-EPMC4729882 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Xu Zheng Zhong ZZ Chen Xiang X Hu Ting T Meng Chuang C Wang Xiao Bo XB Rao Yan Y Zhang Xiao Ming XM Yin Yue Lan YL Pan Zhi Ming ZM Jiao Xin An XA
Frontiers in cellular and infection microbiology 20160128
Mycobacterium bovis bacillus Calmette-Guérin (BCG) is currently the only vaccine available for preventing tuberculosis (TB), however, BCG has varying success in preventing pulmonary TB. In this study, a recombinant BCG (rBCG::Ag85A) strain overexpressing the immunodominant Ag85A antigen was constructed, and its immunogenicity and protective efficacy were evaluated. Our results indicated that the Ag85A protein was successfully overexpressed in rBCG::Ag85A, and the Ag85A peptide-MHC complexes on d ...[more]