Ontology highlight
ABSTRACT:
SUBMITTER: Peng B
PROVIDER: S-EPMC3519677 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Peng Bo B Gu Yixue Y Xiong Yan Y Zheng Guopei G He Zhimin Z
PloS one 20121210 12
We recently reported that TCRP1, a novel multidrug-resistance associated human gene, can mediate cisplatin resistance in OSCC cells. However, the molecular mechanism underlying this role of TCRP1 remained to be elucidated. In this study, by using Human Toxicology and Drug Resistance Microarray, we identified 30 genes with significantly different expression levels between Tca/PYM and TCRP1 knockdown cell lines. Co-immunoprecipitation experiments and GST-pull down assays showed that metallothionei ...[more]